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Multiple Sclerosis- Clinically Isolated Syndrome

Title: "State of the Art Diagnosis and Management of Clinically Isolated Syndrome" Release Date: September 23, 2010 Expiration Date: September 23, 2011 Estimated time to complete activity each part of this activity: 30 minutes There are no prerequisites. Presented by: The Johns Hopkins University School of Medicine Acknowledgement of Commercial Support: Supported by an educational grant from Biogen Idec Learning Objectives After viewing the program, the participant should demonstrate the ability to: * Outline the currently accepted and proposed criteria for the diagnosis of MS following a presentation of CIS * Explain how newer proposed criteria may simplify MS diagnosis by enabling a diagnosis to be made after a single clinical event * Recall that the long-term outcome of high-risk CIS is similar to clinically definite MS * Discuss the benefit of early treatment of high-risk CIS over delayed treatment based upon results of several recent clinical trials * Recognize the ‘radiologically isolated syndrome’ The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity. Program Overview The classic diagnosis of multiple sclerosis (MS) requires evidence of inflammatory demyelination of the CNS, which is disseminated in both space and time. Confidently making the diagnosis following a single episode of optic neuritis, brainstem syndrome or partial myelitis -- the clinically isolated syndromes (CIS) -- should be the goal of contemporary care, as clear benefit can now be offered through early therapy. By building on the pre-MRI criteria of Poser, and using enhancements proposed by others in the 1980s, 1990s, and 2000, the more widely-accepted McDonald criteria were developed in 2001 and revised in 2005. More recently, advancements have been suggested that strive to make diagnostic criteria simpler, while decreasing possible delay in the institution of effective therapy.

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